Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
“It is exceptionally unlikely that we would be witnessing a record year of warmth, during a record-warm decade, during a several decades-long period of warmth that appears to be unrivaled for more than a thousand years, were it not for the rising levels of planet-warming gases produced by the burning of fossil fuels,” Michael E. Mann, a climate scientist at the Pennsylvania State University, said in an email.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
'I just want to stay professional. I don't want them to think I'm a fangirl. I'm one of the performers and I'm not just a background dancer, I'm the dancer.'
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
*Awards presented during the Creative Arts Emmy ceremony Sept. 10-11.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
You might think Hawaiian has it relatively easy, since its flights rarely have to contend with the kind of challenging weather conditions found on the mainland. Hawaiian perennially rates high in on-time performance rankings, topping the most recent DOT list i n September. It recently announced it will branch well beyond its island home with non-stop service to Beijing.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The government's next snapshot of the job market, due Friday, will be distorted by Sandy, which devastated the Northeast in late October, leaving many jobless. Economists say Sandy could temporarily knock anywhere from 100,000 to 150,000 off of the government's jobs tally for November, resulting in job growth of under 100,000 or even much less.[qh]
As the unstoppable Nazi forces roll across Western Europe and the threat of invasion is imminent, and with an unprepared public, a skeptical King, and his own party plotting against him, Churchill must withstand his darkest hour, rally a nation, and attempt to change the course of world history.
Trends and targets in antiviral phototherapy
根据中国海关总署(General Administration of Customs)发布的数据，12月份以美元计的出口额同比减少6.1%至2094.2亿美元。这一跌幅比经济学家预期的中数多了2.1个百分点，也大于11月份修正后1.6%的跌幅（修正前该数字为增长0.1%）。
"Under the leadership of the CPC Central Committee, we'll broaden judicial cooperation with relevant countries so that there will be no 'safe heaven' for corrupt fugitives," said La Yifan, director of the CCDI's International Cooperation Department.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Their positional matchups with both Cleveland and Boston now look much more palatable.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Employment is the foundation of economic development. It creates wealth and it is the major source of household income.
Diagnostic technologies for COVID-19: a review
“Brands that are known for going it alone are partnering with unexpected allies,” Gilbert says. “If you dig into Apple’s investment, the special projects team reads like a who’s who list of some of the best talent in the world coming from every sector imaginable.”
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
A vibrant ETF market would depend on the evolution of fee-based distribution networks. Mark Talbot, managing director of Asia-Pacific at Fidelity International, says the distribution infrastructure is holding back retail demand.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Tesla has an order backlog of $226 million. At the production run rate of 1000 cars a week expected at the end of 2014, that translates to a 30-week backlog.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
China has recently made majordecisions about its economic future. On November 15, 2013, China announceddramatic new social and economic policies contemplating much greater relianceon market forces than it has in the past and inviting private-sectorparticipation and foreign competition in industries long previously controlledby the central government. It also relaxed its one-child policy, openingthe country and its people to vast new opportunities and inspiring new hopes anddreams.
After rising every year since 2008 global gold supply plateaued last year, according to the World Gold Council. In China, the world’s biggest producer, it fell by a record 9 per cent, the second time output has fallen in the country since 1980.
The Thomson Reuters Top 100 global innovators program identifies innovators annually through an in-depth analysis based on a series of patent-related metrics that analyze what it means to be truly innovative.
Influenza neuraminidase: A druggable target for natural products
Premiered on Jan 29, the drama received 7 points out of 10 on the country's popular review website Douban.
其他人将想方设法利用技术来帮助人们减少上网时间。谷歌(Google)前雇员特里斯坦哈里斯(Tristan Harris)发起的“时光莫虚度”(Time Well Spent)运动正在吸引人气，该运动鼓励设计者理解他们所控制的微妙的心理力量，以解决其所称的“数字注意力危机”。据Recode报道，曾经在Pinterest和Facebook工作的蒂姆肯德尔(Tim Kendall)，计划成立一家专注于对抗设备上瘾的初创公司。
We will ensure workplace safety and people's lives.
Some 18.1 million people, for example, want a good full-time job but can't find one, an unusually high number 5 1/2 years into a recovery. And despite a sharp decline in the number of people out of work six months or longer, that figure is still higher than at any time before the 2007-09 recession.
Going into the debate at Lynn University in Boca Raton, Florida, Obama had an inbuilt advantage on foreign policy and security. As president, with access to daily briefings by intelligence analysts, diplomats and generals, he is better briefed and it showed as he dominated Romney in the first half of the debate.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
"Overall this ranking of Asia's best 300 universities proves what a dynamic, diverse and competitive higher education region the continent is becoming -- and China is a key part of that development," said Baty.
Don't mistake the lack of a late flurry for an uneventful deadline:
The role of biosensors in the detection of emerging infectious diseases
“The auction market is extremely selective,” said Henry Pettifer, the head of old master paintings at Christie’s, whose sale total had been dented by a 15th-century Flemish Madonna and child by Hans Memling that the auction house had sold privately for more than 3.5 million and had withdrawn from the sale. “The availability of fresh material is limited,” he added, alluding to how few museum-quality works are in private hands.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Those quickly sold out, locking out the vast majority of fans in soccer-mad Brazil.
Zheng Gang, a member of the CPPCC National Committee and deputy mayor of Danzhou city, Hainan province.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Despite the criticism, Mayer defended her decision to Fortune in April and said that the move was "wrongly perceived as an industry narrative." Mayer said she needed employees to work in the office to encourage collaboration and innovation from workers. So far it looks like her controversial move may be helping the business: Yahoo's stock is up more than 100% since Mayer took over in 2012.
Jiang Yiyi at the China Tourism Academy suggests China adopt a long-term national plan to improve the country's image and investment in inbound tourism to attract more visitors.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
4. Precious metals: 'Going dark! Economic cycles point downward'
John Stevenage, chief executive of British Mensa, said he was delighted for Nishi. He said: 'I hope she will make full use of her membership to meet new, like-minded people and challenge herself. Joining Mensa opens the door to an international network of more than 100,000 people and many members make friends for life.
Inhibition of SARS coronavirus helicase by bismuth complexes
在此次上榜的5所中国学院当中，上海高级金融学院排名最高，领先于北京大学光华管理学院(Guanghua School of Management at Peking University)和清华大学经济管理学院(School of Economics and Management, Tsinghua University)，后两家学院分别排名第17位和第18位。
13. iPhone 提醒
It's the summer of 1983, and precocious 17-year-old Elio Perlman is spending the days with his family at their 17th-century villa in Lombardy, Italy. He soon meets Oliver, a handsome doctoral student who's working as an intern for Elio's father. Amid the sun-drenched splendor of their surroundings, Elio and Oliver discover the heady beauty of awakening desire over the course of a summer that will alter their lives forever.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
More than 40 percent of consumer goods exported to China last year through e-commerce platforms fell short of standards, China's top quality watchdog said.
西尔万·埃索(Sylvan Esso)，《咖啡》(Coffee)， Partisan
The film critics of The New York Times — Manohla Dargis and A. O. Scott — share their picks for the best movies of the year.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
“In the drama, romance is the protagonist’s only pursuit. It seems that the meaning of her life is to have a romantic relationship with a Prince Charming. No, not only one, but three or four,” Douban user Jiuyuehuashang said.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Apple Inc.'s Chief Executive Officer Steve Jobs is shown in this combination photo of file photographs dating (top row L to R) July 2000, November 2003, September 2005, (bottom L to R) September 2006, January 2007 and September 2008. Jobs will take a medical leave of absence until the end of June because his health problems are "more complex" than he had thought, shocking investors and sending the company's shares down as much as 10 percent on January 14, 2009.
Collins grew up in rural, apartheid-era South Africa in the 1970s. Her childhood inspired her to focus on empowering women living below the poverty line through grassroots efforts. The Wonderbag, which was inspired by watching her grandmother cook with cushions, uses heat retention technology to cook food for 8-12 hours without the need for additional fuel. Collins witnessed the benefits African women received from using Wonderbags, reducing the amount of time they spent collecting firewood. For every bag sold, another is donated to a household in Africa, and in the past four years, the Wonderbags have found themselves in 600,000 African homes. Collins has launched the Wonderbag in the U.S. on Amazon, and hopes to sell the products via other retailers by 2014.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Fantastic Beasts and Where to Find Them will be released worldwide on November 18, 2016.
Logan's claws are slow on the draw and his self-healing powers are on the fritz, but he's committed to caring for his mentor Charles Xavier (Patrick Stewart, so good you want to applaud). It's not easy watching Professor X suffer seizures that rattle his telepathic brain. Make no mistake, Logan earns its tears. If Jackman and Stewart are serious about this being their mutual X-Men swan song, they could not have crafted a more heartfelt valedictory.
Deciding what to blog about can become time consuming. HitTailanalyzes the data in your Google Webmaster Tools account and makes recommendations for long-tail words to write about. In addition, HitTail has a network of skilled writers who can create the content for you.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
The two pleasure devices both made of bronze date back more than 2000 years to China's Han Dynasty (206 BC–220 AD).
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
The truth is, to shut our door to the outside world would not help China do its own things well, so China will continue to open to the outside world, with this opening-up being a gradual process.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
“中国政府将GDP增长目标设定为7.5%，并努力将通胀保持在可控水平，很令人欣慰。这不仅会保持中国经济的繁荣，还将促进地区经济和全球经济的发展，印尼也将从中受益。”Imron Cotan, Indonesian ambassador to China
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
It even featured in the March 19, 1870, issue of Scientific American magazine. Made by Thomas Luders from Olney, Illinois, and called a "pedespeed," the wheels then were much smaller, measuring around 36 centimeters (15 in) in diameter. Luders also said the skates could be used by anybody, irrespective of their physique. He himself was a large, heavy man, and he claimed he could use them for two straight hours without getting tired. Another version of wheel skates, appearing in 1923, had its tires on the inside of the foot rather than outside. (Other than the size of the wheels, the main improvement made by Chariot Skates is the small tire at the back of the bigger tire for increased stability.)
Four factors should fuel the jobs recovery in 2013:[qh]
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Rather than strangling the doctor (difficult, due to his injury) Jalava took the corny line as inspiration. He decided to go ahead and actually build a prosthetic finger that contains two gigabytes of digital storage. He can now jack his finger into a computer just by peeling back the nail to expose the USB plug. He can also remove the entire finger at any time and hand it to a friend to use.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Best Companies rank: 61
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Michael Smurfit Graduate Business School at University College Dublin showed the best overall progress, moving up 21 places to 48. Guanghua School of Management at Peking University returns to the ranking at 38, after missing last year due to a low response rate from participants.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
"If reform implemented 30 years ago solved the problem of ideology, then, at present, reform is to solve the problem of interests. Reform at present is actually like cutting our own with a knife, and we all need to be determined and must strengthen our confidence." WANG YANG, NPC deputy and member of the Political Bureau of the Communist Party of China Central Committee
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
3.The Andrea Yates Trial Inspired Desperate Housewives
Their inclusion has come at the expense mainly of European companies, signalling the shift in economic power towards the east. There is only one Indian brand in the top 100 ranking — HDFC Bank. Russian, Mexican and Brazilian brands have fallen out of the ranking in the past few years — a sober reflection of the changing fortunes of these emerging markets.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Li Yi, a Shanghai-based independent IT expert, told the Global Times the surge in the number of smartphones was the primary reason for the growth in Net users.
Last year, Islamic State militants seized 49 Turkish hostages from Turkey's consulate in Mosul and held them for more than three months before releasing the group. Those hostages included diplomats, soldiers and children.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Taken alongside data released in the past few days, and it doesn't make things easier. The country is still struggling with deflation and household spending slumped last month. But retail sales data released this morning topped estimates.
Tuesday’s event at Apple’s new Cupertino headquarters is expected to reveal its much-anticipated 10th-anniversary iPhone, offering significant upgrades to the smartphone’s display, camera and overall design.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Other high points for the school include being first for alumni international mobility, second for international experience and third for job placement.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Sweden’s foreign minister, Margot Wallstrom, a proponent of a “feminist foreign policy,” opened up to Ellen Barry about her abuse at the hands of an old boyfriend when she was a young woman, something she had never said publicly before.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
When Finnish programmer Jerry Jalava had a motorcycle accident in 2008, he faced a double tragedy. First, he lost his finger, an obvious problem for anyone who types for a living. Second, he had to deal with a medical team who thought they were comedians—learning of his profession, one surgeon joked that Jalava should go out and buy a “USB finger drive.”
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Magic show (Lu Chen)
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
We learned about the causes and consequences of rising obesity around the world.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Wishing you all the blessings of a beautiful season.愿你拥有美丽的新年所有的祝福。
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
It’s wall-to-wall pure pop heaven, crackling with originality and dark humor, teeming with action sequences so perfectly timed and executed you almost want to run out of the theater on the spot so you can call a friend and rave about it — but you wouldn’t dare leave your seat because you wouldn’t want to miss a frame of this brilliant, pulse-quickening gem.
Her predecessor David Cameron placed fifth in CNNMoney's previous ranking in March 2015 with his salary of ￡142,500, then worth $214,800. May is only seventh.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
由西班牙IQS商学院、台湾辅仁大学(Fu Jen Catholic University)和旧金山大学(University of San Francisco)三家合办的管理学硕士项目排名升幅最大。其全球创业管理硕士项目的排名上升34位，至第43位，逆转了去年下滑19名的势头。这是唯一一个在三大洲授课的项目，其在国际课程体验方面排名第一。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Hidrate Spark 2会通过移动App跟踪你的水摄入量和记录你一天喝了多少盎司的水，还可以根据在有盎司数标识的水瓶里灌了几次水来跟踪你的饮水量。
I know this takes time, but it'll ensure you really know your stuff. And that's why you're going to school. Right?
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
The new figures come as Mr Duterte fends off criticism at home and abroad over his anti-drugs campaign, which has seen 600,000 potential suspects voluntarily turn themselves in to authorities.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Good health, good luck and much happiness throughout the year.
Anti-HIV drug repurposing against SARS-CoV-2
美国全国地产经纪商协会(National Association of Realtors)的数据显示，自去年7月份以来美国成屋销量每月都在下滑。这和美国借贷成本上升是同步的。由于美联储暗示将缩减购债计划的规模，整个经济的借贷成本不断上升。
"Another interesting aspect of this year's list is that more short numerical passwords showed up even though websites are starting to enforce stronger password policies."
Length-scale dependence of protein hydration-shell density
But that kind of emotional identification gets lost on the runway, and the retail floor. And then we are left with what?
Japanese Three: Honda treads water while it waits for bold new designs from its Americanized management team to reach market, particularly the Acura NSX super car, which has been on the auto show circuit now for several years. Focused now on his legacy, CEO Carlos Ghosn drives executives even harder to meet targets in his latest three-year plan while he grooms a successor. As for Toyota, Automotive News declares that it is firing on “all cylinders” before its move from Southern California with fresh products in key segments.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Doing more to unleash the potential of domestic demand
Female founders in Silicon Valley will raise more money next year, as sexual harassment scandals have forced investors to rethink their habit of backing ventures founded by mainly young, white men. Some start-ups founded by men pursued by rumours of unsavoury pasts will not get funding, even if they are a good investment proposition.
About this collection
While at least four engines tend to repeat from one year’s 10 best list to the next, only two of last year’s powerplants remain recognized for 2014, the Honda Accord’s peppy and fuel-efficient 3.5-liter V6 and the powerful supercharged 3.0-liter V6 featured in the Audi S5.